San Francisco @ Seattle (-8.5): Seattle's 12th man makes a difference in home games and all that, but the way I see it too many pivotal offensive players are out due to injury for the Seahawks to win by this much. If there's one thing the 49ers ought to be able to achieve on defense, it's limit what Julius Jones can do. This one has the makings of a low-scoring affair, not what you'd generally want to happen if you're picking Seattle to cover.

Tennessee @ Cincinnati (-1): With the beating Cincy's defense is likely to receive at the hands of running backs LenDale White and Chris Johnson, all Kerry Collins has to do is keep the turnovers at a minimum. And he's not a bad backup quarterback. The Titans defense looks really good. The Bengals offense? Not so good.

Buffalo  @  Jacksonville (-6): Buffalo got it done last week on defense and spectacular special teams play. News for the Jags offense took a turn for the worse at the announcement that now three starting linemen are out until at least October. Probably a gritty, brutal game all the way to the finish. Are the Bills up to the task? I think they are.