Let's go ahead and get a jump on next weekend while good defensive matchups can be had without fighting the WW.
Here's your top 5.
Buffalo, Buffalo, Buffalo - only owned in about 32% of Yahoo leagues so if they are there grab them now before someone else realizes they are playing Arizona in week 6.
Atlanta - Solid defense this year playing at home against a putrid Oakland Raiders offense. Grab em and run like you stole it!
Miami - Playing against St Louis. The Rams only had 1 WR and he busted his shoulder. Miami has put up decent numbers fantasy wise on D/ST and this looks like one of their better matchups.
Detroit - Yeah they aren't awesome, but it's the Turnover machine Michael Vick. Always pick 6 potential.
Cincinnati going against Cleveland. I'm not a big fan of Cincy, but this is a pretty nice matchup on paper.