Strength of schedule is calculated from the opponents projected fantasy points allowed for the DEF position. The best rating is +16 which gives the player the advantage against the defense and indicates an easy opponent, the worst rating is -16 which gives the defense the advantage and indicates a tough opponent.
They've had the luxury of playing the Giants and Redskins. Now they face a much tougher offense and quarterback. Wilson hasn't been sharp from in the pocket so look for them to try and force him to throw.
The 49ers lost safety Donte Whitner and cornerback Tarrell Brown but found more than suitable replacements in Antoine Bethea (Indianapolis) and Chris Cook (Minnesota). Year in and year out this is a punishing defensive unit that doesn't rack up huge special team points but will amass close to 40 sacks and a handful of defensive touchdowns while limiting yards and points allowed.