Here is a list of all of the fantasy-relevant Week 5 injuries, along with the fantasy impact:
Dak Prescott, QB, Dallas Cowboys
Prescott left Sunday’s game against the Giants with a severe right ankle injury in the third quarter. He suffered the injury at the end of a run, when his ankle bent sideways during the tackle. He had to be carted off the field and was immediately taken to the hospital. After the game, Michael Gehlken of the Dallas Morning News reported that Prescott suffered a compound fracture and dislocation of his right ankle, and he underwent season-ending surgery.
This is a tough blow for the Cowboys and for Prescott, and the team will have to move forward with Andy Dalton under center. There’s no doubt that Dalton will be a significant downgrade from Prescott, but his nine years of starting experience make him a stable option for the team. With Dalton at quarterback, Amari Cooper and CeeDee Lamb should remain top-25 wide receivers, while Michael Gallup will continue to be a boom-or-bust flex play. Given the strong receiving corps in Dallas, Dalton, himself, should also enter the top-20 conversation at quarterback. It would be hard to trust him as your season-long starter, but he could be a decent bye week fill-in.
Dalvin Cook, RB, Minnesota Vikings
Cook left Sunday’s game against the Seahawks with a groin injury in the third quarter. He suffered the injury during a catch-and-run, when he took an awkward step and came up limping. He later returned to the game for one play, but he looked uncomfortable and permanently exited after that. After the game, Chris Tomasson of the St. Paul Pioneer Press reported that Cook will have an MRI on Monday and that the team doesn’t know if he’ll be able to play in Week 6.
We’ll have to wait for the MRI results to know the true severity of Cook’s injury, but it looks like it could be serious enough to cost him some games. If Cook is out for any period of time, then Alexander Mattison would be the team’s main running back, with Mike Boone backing him up. Since the beginning of last season, Mattison has been solid when asked to fill in for Cook, including on Sunday when he rushed 20 times for 112 yards (almost all of which came after Cook’s injury). Mattison isn’t nearly the dynamic athlete that Cook is, but he runs like a hammer and can wear defenses down over the course of a game, bringing an element of power that Cook lacks. Mattison is easily a top-20 running back as long as Cook is out, and he’s a top-12 option in a good Week 6 matchup against the Falcons.
D.J. Chark, WR, Jacksonville Jaguars
Chark left Sunday’s game against the Texans with an ankle injury late in the fourth quarter, and he did not return to the game. The Jaguars have not provided any updates on the injury.
We don’t know anything about the seriousness of the injury at this point, and it’s possible that Chark could have returned if there had been more time left in the game. For now, all you can do is wait for an update from the team, which may not come until the first practice report on Wednesday. If Chark is forced to miss Week 6 against the Lions, then Keelan Cole, Laviska Shenault, and Chris Conley would be Jacksonville’s starting wideouts. Shenault — a second-round rookie — is the most interesting option out of that group because of his versatility, big-play ability, and an impressive combination of size and quickness. Cole, on the other hand, has far less upside, but his nose for the end zone makes him an option in deeper leagues. If Chark is out, you can consider Shenault a top-35 option and Cole a top-50 option, while Conley is best left on waivers.