Christian McCaffrey, San Francisco (vs. Arizona)
Austin Ekeler, Los Angeles Chargers (vs. Las Vegas) [INJURED]
Saquon Barkley, New York Giants (vs. Seattle) [INJURED]
Bijan Robinson, Atlanta (at Jacksonville)
Derrick Henry, Tennessee (vs. Cincinnati)
Tony Pollard, Dallas (vs. New England)
Josh Jacobs, Las Vegas (at Los Angeles Chargers)
ROLL THEM OUT
Derrick Henry, Tennessee (vs. Cincinnati): That Henry needs mentioning at all after 20 yards on 11 carries last week is rather depressing. But Cincinnati has been soft against the run, giving up 151.7 rushing yards per contest.
Alexander Mattison, Minnesota (at Carolina): After a slow start to the season, Mattison finally got going last week with 125 total yards against the Los Angeles Chargers. This week he faces a Carolina defense that has surrendered the third-most fantasy points to running backs.
Dameon Pierce, Houston (vs. Pittsburgh): Pierce has been a significant disappointment to date this season, but Sunday’s matchup with a Pittsburgh team allowing over 150 yards per game on the ground could be just what it takes to get the second-year back going.
Javonte Williams, Denver (at Chicago): Williams hasn’t been especially productive this year, but he has been Denver’s clear lead back. That could mean good things against a woeful Chicago defense surrendering the most fantasy points in the NFC to running backs.
SIT THEM DOWN
Gus Edwards, Cleveland (vs. Baltimore): Edwards is in the concussion protocol, but even if he clears it, he belongs on fantasy benches in Week 4. Cleveland just completely shut down Derrick Henry and have allowed just 52 yards a game on the ground.
Joe Mixon, Cincinnati (at Tennessee): The entire Cincinnati offense has struggled to get going this season, and now Cincinnati faces a Tennessee run defense that ranks fourth in rushing yards per game allowed and 29th in points per reception (PPR) league points given up to running backs.
Brian Robinson, Washington (at Philadelphia): Robinson has been a pleasant surprise for fantasy managers this year — he’s seventh in PPR points among running backs. But Philadelphia is the only team in the National Football League that has allowed less than 50 rushing yards per game this year.
Rachaad White, Tampa Bay (at New Orleans): White was shut down by Philadelphia in Week 3, including being stuffed in the end zone for a safety. Now he draws a New Orleans defense that has given up the seventh-fewest fantasy points to running backs so far this year.